Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (N-Term) antibody

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14)

Synonyms: TR2, ATAR, HVEA, HVEM, LIGHTR, MGC108903, TNFRSF14

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN238265

Additional Information

Alternative name: Tumor Necrosis Factor Receptor Superfamily 14 (TNFRSF14)

Immunogen: Synthetic peptide corresponding to 15 amino acids near the amino terminus of human TNFRSF14 (Genbank accession No. Q92956)

Format: Liquid

Description: Rabbit anti TNFRSF14 (NT) Rabbit Antibody to Human Tumor Necrosis Factor Receptor Superfamily 14 (TNFRSF14) N-terminal

Specificity: Reacts with human and mouse TNFRSF14. TNFRSF14 was initially identified as the Herpesvirus entry mediator (2) and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT alpha), activates the transcription factors NF-kappaB and AP-1 (3,4). Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity.

Application Details

Application Notes: Suitable for use in Western blot (1?2ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Concentration: Lot specific

Purification: Immunoaffinity purified

Buffer: PBS. Preservative: 0.02% Sodium azide

Storage: Store (up to one year) at 2-8°C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Restrictions: For Research Use only

Publications

Montgomery, Warner, Lum et al.: "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family." in: Cell, Vol. 87, Issue 3, pp. 427-36, 1996 (PubMed).

Marsters, Ayres, Skubatch et al.: "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14029-32, 1997 (PubMed).

Mauri, Ebner, Montgomery et al.: "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator." in: Immunity, Vol. 8, Issue 1, pp. 21-30, 1998 (PubMed).

Granger, Rickert: "LIGHT-HVEM signaling and the regulation of T cell-mediated immunity." in: Cytokine & growth factor reviews, Vol. 14, Issue 3-4, pp. 289-96, 2003 (PubMed).