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HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody

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(375), (8), (7), (3), (1)
(241), (110), (27), (6), (3), (1)
Clonality (Clone)
Monoclonal ()
(46), (41), (30), (22), (13), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Blocking Antibody (Inhibition)
(182), (170), (165), (83), (62), (55), (45), (43), (37), (32), (17), (7), (2), (2), (1), (1), (1), (1)
Pubmed 7 references available
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Quantity 0.1 mg
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Immunogen HLA-B27 transgenic mice were imunized with H-2 identical murine cells transfected withand expressing genes encoding HLA-G and human beta2-microglobulin.
Clone 87G
Isotype IgG2a
Specificity The antibody 87G recognizes both membrane-bound and soluble forms of HLA-G (HLA-G1 and HLA-G5).
Characteristics Synonyms: HLA-6.0, HLAG, MHC class I antigen G, HLA class I histocompatibility antigen
Purification Ficin digestion of the IgG followed by protein-A affinity chromatography to remove the remaining intact IgG or Fc fragments.
Alternative Name HLA Class I alpha G / HLA-G (HLAG Antibody Abstract)
Background HLA-G belongs to the MHC Class I molecules (MHC Class Ib, nonclassical) and it is expressed on the surface of trophoblast cells.Synonyms: HLA class I histocompatibility antigen, HLA-6.0, HLAG, MHC class I antigen G
Gene ID 3135
UniProt P17693
Application Notes Suitable for Blocking assay (10 μg/1 ml).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS, pH 7.4 without preservatives.
Preservative Without preservative
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (ABIN238378) anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody
Background publications LeMaoult, Caumartin, Daouya et al.: "Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells." in: Blood, Vol. 109, Issue 5, pp. 2040-8, 2007 (PubMed).

Shobu, Sageshima, Tokui et al.: "The surface expression of HLA-F on decidual trophoblasts increases from mid to term gestation." in: Journal of reproductive immunology, Vol. 72, Issue 1-2, pp. 18-32, 2006 (PubMed).

Rouas-Freiss, Moreau, Ferrone et al.: "HLA-G proteins in cancer: do they provide tumor cells with an escape mechanism?" in: Cancer research, Vol. 65, Issue 22, pp. 10139-44, 2005 (PubMed).

Hackmon, Hallak, Krup et al.: "HLA-G antigen and parturition: maternal serum, fetal serum and amniotic fluid levels during pregnancy." in: Fetal diagnosis and therapy, Vol. 19, Issue 5, pp. 404-9, 2004 (PubMed).

Sageshima, Ishitani, Omura et al.: "Necrotic feature of the trophoblasts lacking HLA-G expression in normal and pre-eclamptic placentas." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 49, Issue 3, pp. 174-82, 2003 (PubMed).

Poláková, Krcová, Kuba et al.: "Analysis of HLA-G expression in malignant hematopoetic cells from leukemia patients." in: Leukemia research, Vol. 27, Issue 7, pp. 643-8, 2003 (PubMed).

Menier, Saez, Horejsi et al.: "Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules." in: Human immunology, Vol. 64, Issue 3, pp. 315-26, 2003 (PubMed).

Catalog No. ABIN238378

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