You are viewing an incomplete version of our website. Please click to reload the website as full version.

LAMP1 antibody (Lysosomal-Associated Membrane Protein 1)

Details for Product anti-LAMP1 Antibody No. ABIN238392, Supplier: Log in to see
Antigen
  • AI196048
  • CD107a
  • Lamp-1
  • LAMPA
  • LEP100
  • LGP120
Reactivity
Human
366
204
139
54
45
38
13
3
2
Host
Mouse
294
109
73
2
Clonality (Clone)
Monoclonal ()
Conjugate
This LAMP1 antibody is un-conjugated
46
38
28
21
13
13
8
8
7
7
7
6
6
6
6
6
6
5
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
247
241
170
167
102
90
77
47
44
19
14
14
12
4
3
3
2
2
2
1
1
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen U937 human Caucasian hystiocytic lymphoma cell line.
Clone B-T47
Isotype IgG1
Specificity The antibody B-T47 recognizes CD107a, a 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.
Cross-Reactivity (Details) Species reactivity (tested):Human
Characteristics Synonyms: LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1, CD107Antigen-like Family Member A
Purification Purified by protein A
Alternative Name CD107a / LAMP1 (LAMP1 Antibody Abstract)
Background CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2 % of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.Synonyms: CD107 Antigen-like Family Member A, LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1
Gene ID 3916
UniProt P11279
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Suitable for Flow Cytometry and Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized
Preservative Azide free
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, 2011 (PubMed).

Huynh, Eskelinen, Scott, Malevanets, Saftig, Grinstein: "LAMP proteins are required for fusion of lysosomes with phagosomes." in: The EMBO journal, Vol. 26, Issue 2, pp. 313-24, 2007 (PubMed).

Barrachina, Maes, Buesa, Ferrer: "Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease." in: Neuropathology and applied neurobiology, Vol. 32, Issue 5, pp. 505-16, 2006 (PubMed).

Sarafian, Marinova: "Lysosomal membrane-associated glycoproteins are differentially expressed in acute and chronic human thymic involution." in: Acta biologica Hungarica, Vol. 57, Issue 3, pp. 315-22, 2006 (PubMed).

Eskelinen: "Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy." in: Molecular aspects of medicine, Vol. 27, Issue 5-6, pp. 495-502, 2006 (PubMed).

Grützkau, Smorodchenko, Lippert, Kirchhof, Artuc, Henz: "LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 61, Issue 1, pp. 62-8, 2004 (PubMed).