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Details for Product No. ABIN238392

Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody

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Antigen
Synonyms LAMPA, CD107a, LGP120, AI196048, Lamp-1, LEP100
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
Pubmed 6 references available
Catalog no. ABIN238392
Quantity 0.1 mg
Price
335.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen U937 human Caucasian hystiocytic lymphoma cell line.
Clone B-T47
Isotype IgG1
Characteristics Synonyms: LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1, CD107Antigen-like Family Member A
Purification Purified by protein A
Alternative Name CD107a / LAMP1
Background CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is amajor constituent of lysosomal membrane, 1-2% of total CD107a is found also on theplasma membrane. The LAMP proteins are involved in lysosome biogenesis and arerequired for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity isobserved in neurones, and in glial cells surrounding senile plaques in Alzheimers diseasecases and is localized mainly in medullary epithelial cells, single macrophages andlymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.
UniProt P11279
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Suitable for Flow Cytometry and Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized
Preservative Azide free
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Grützkau, Smorodchenko, Lippert et al.: "LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 61, Issue 1, pp. 62-8, 2004 (PubMed).

Barrachina, Maes, Buesa et al.: "Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease." in: Neuropathology and applied neurobiology, Vol. 32, Issue 5, pp. 505-16, 2006 (PubMed).

Eskelinen: "Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy." in: Molecular aspects of medicine, Vol. 27, Issue 5-6, pp. 495-502, 2006 (PubMed).

Sarafian, Marinova: "Lysosomal membrane-associated glycoproteins are differentially expressed in acute and chronic human thymic involution." in: Acta biologica Hungarica, Vol. 57, Issue 3, pp. 315-22, 2006 (PubMed).

Huynh, Eskelinen, Scott et al.: "LAMP proteins are required for fusion of lysosomes with phagosomes." in: The EMBO journal, Vol. 26, Issue 2, pp. 313-24, 2007 (PubMed).

Hrdinka, Dráber, Stepánek et al.: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, 2011 (PubMed).

Alternatives for antigen "Lysosomal-Associated Membrane Protein 1 (LAMP1)", type "Antibodies"
Hosts (81), (60), (34), (1)
Reactivities (125), (75), (40), (9), (7), (6), (3), (2)
Applications (95), (83), (29), (29), (26), (26), (24), (21), (15), (10), (8), (2), (1), (1), (1), (1)
Conjugates (21), (17), (14), (9), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (8), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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