Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody (PE)

Antigen: Lysosomal-Associated Membrane Protein 1 (LAMP1)

Synonyms: LAMPA, CD107a, LGP120

Clonality: Monoclonal (B-T47)

Host: Mouse

Reactivity: Human

Conjugate: PE

Catalog no.: ABIN238393

Additional Information

Characteristics: Synonyms: LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1, CD107Antigen-like Family Member A

Alternative name: CD107a / LAMP1

Swiss-Prot: P11279

Immunogen: U937 human Caucasian hystiocytic lymphoma cell line

Cross-Reactivity: Human

Isotype: IgG1

Clone: B-T47

Description: CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is amajor constituent of lysosomal membrane, 1-2% of total CD107a is found also on theplasma membrane. The LAMP proteins are involved in lysosome biogenesis and arerequired for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity isobserved in neurones, and in glial cells surrounding senile plaques in Alzheimers diseasecases and is localized mainly in medullary epithelial cells, single macrophages andlymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.

Specificity: The antibody B-T47 recognizes CD107a, a 100-120 kDa glycoprotein expressed mainly onlysosomal, but also on the plasma membrane. Species: Human. Others not tested.

Application Details

Application Notes: Suitable for Flow Cytometry and Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Buffer: PBS containing 15 mM sodium azide as preservative and 0.2% (w/v)high-grade BSA (protease free) as stabilizer.Label: R-Phycoerythrin (PE)

Storage: Store the antibody in the dark at 2-8°C. Do Not Freeze! . Avoid prolonged exposure to light. Shelf life: One year from despatch.

Research Area: CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only