Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody

Details for Product No. ABIN238438
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Antigen
Synonyms AI196731, APO1, APT1, CD95, TNFR6, Tnfrsf6, lpr, TNFRSF6, ALPS1A, APO-1, FAS1, FASTM, A630082H08Rik, FAS
Reactivity
Human
(465), (95), (64), (12), (10), (4), (2), (1), (1), (1)
Host
Mouse
(296), (245), (8), (6), (5), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(50), (43), (37), (13), (8), (4), (4), (4), (4), (4), (4), (4), (4), (2), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(243), (228), (139), (82), (82), (67), (62), (40), (38), (31), (31), (13), (11), (8), (7), (7), (3), (3), (3), (3), (2), (2), (2), (2), (1)
Pubmed 6 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN238438
308.00 $
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Immunogen HUT-78 human T cell lymphoma cell line
Clone LT95
Isotype IgG1
Specificity The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Characteristics Synonyms: FASLG receptor, Apo-1 antigen, APT1, FAS1, TNFRSF6, Tumor necrosis factor receptorsuperfamily member 6
Purification Precipitation methods and Ion exchange chromatography.
Alternative Name CD95 / FAS
Background CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6
Gene ID 355
UniProt P25445
Application Notes Flow Cytometry. Immunohistochemistry (paraffin sections). Positive tissue: tonsil
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Tris buffered saline (TBS), pH 8.0, 15 mM Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody
Background publications Scaffidi, Fulda, Srinivasan et al.: "Two CD95 (APO-1/Fas) signaling pathways." in: The EMBO journal, Vol. 17, Issue 6, pp. 1675-87, 1998 (PubMed).

Park, Thomsen, Frevert et al.: "Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6209-16, 2003 (PubMed).

Nakamura, Kakinuma, Amada et al.: "Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors." in: Bioorganic & medicinal chemistry, Vol. 12, Issue 23, pp. 6209-19, 2004 (PubMed).

Drosopoulos, Roberts, Cermak et al.: "Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway." in: The Journal of biological chemistry, Vol. 280, Issue 24, pp. 22856-67, 2005 (PubMed).

Guo, Zhang, Tang et al.: "Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines." in: Blood, Vol. 106, Issue 6, pp. 2033-41, 2005 (PubMed).

Brumatti, Yon, Castro et al.: "Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide." in: Experimental cell research, Vol. 314, Issue 3, pp. 554-63, 2008 (PubMed).

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