Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody

Details for Product No. ABIN238438
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Antigen
Synonyms AI196731, APO1, APT1, CD95, TNFR6, Tnfrsf6, lpr, TNFRSF6, ALPS1A, APO-1, FAS1, FASTM, A630082H08Rik, FAS
Reactivity
Human
(451), (93), (66), (17), (10), (4), (2), (1), (1), (1)
Host
Mouse
(282), (240), (8), (6), (4), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(49), (38), (30), (12), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(226), (217), (144), (79), (78), (68), (61), (44), (34), (32), (31), (11), (11), (7), (5), (3), (3), (3), (3), (2), (2), (2), (2), (1)
Pubmed 6 references available
Quantity 0.1 mg
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Catalog No. ABIN238438
308.00 $
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Immunogen HUT-78 human T cell lymphoma cell line
Clone LT95
Isotype IgG1
Characteristics Synonyms: FASLG receptor, Apo-1 antigen, APT1, FAS1, TNFRSF6, Tumor necrosis factor receptorsuperfamily member 6
Purification Precipitation methods and Ion exchange chromatography.
Alternative Name CD95 / FAS
Background CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of theTNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular deathdomains, formation of the death-inducing signaling complex (DISC) and activation ofcaspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated atthe DISC, in type II cells low concentration of caspase 8 activates pathway leading to therelease of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokineresponses.
UniProt P25445
Application Notes Flow Cytometry. Immunohistochemistry (paraffin sections). Positive tissue: tonsilOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 20 mM Tris/HCl, pH 7.4 with 15 mM sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody
Background publications Scaffidi, Fulda, Srinivasan et al.: "Two CD95 (APO-1/Fas) signaling pathways." in: The EMBO journal, Vol. 17, Issue 6, pp. 1675-87, 1998 (PubMed).

Park, Thomsen, Frevert et al.: "Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6209-16, 2003 (PubMed).

Nakamura, Kakinuma, Amada et al.: "Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors." in: Bioorganic & medicinal chemistry, Vol. 12, Issue 23, pp. 6209-19, 2004 (PubMed).

Drosopoulos, Roberts, Cermak et al.: "Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway." in: The Journal of biological chemistry, Vol. 280, Issue 24, pp. 22856-67, 2005 (PubMed).

Guo, Zhang, Tang et al.: "Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines." in: Blood, Vol. 106, Issue 6, pp. 2033-41, 2005 (PubMed).

Brumatti, Yon, Castro et al.: "Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide." in: Experimental cell research, Vol. 314, Issue 3, pp. 554-63, 2008 (PubMed).

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