Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Endoglin antibody

ENG Reactivity: Human, Pig WB, FACS, IF, IHC (fro) Host: Mouse Monoclonal MEM-229 unconjugated
Catalog No. ABIN238459
  • Target See all Endoglin (ENG) Antibodies
    Endoglin (ENG)
    Reactivity
    • 170
    • 62
    • 44
    • 17
    • 9
    • 3
    • 2
    • 1
    Human, Pig
    Host
    • 107
    • 85
    • 16
    • 1
    • 1
    Mouse
    Clonality
    • 107
    • 102
    • 1
    Monoclonal
    Conjugate
    • 91
    • 27
    • 25
    • 25
    • 15
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Endoglin antibody is un-conjugated
    Application
    • 148
    • 124
    • 58
    • 57
    • 34
    • 19
    • 16
    • 14
    • 14
    • 13
    • 13
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Porcine.
    Characteristics
    Synonyms: ENG, END, HHT1, ORW, ORW1
    Purification
    Protein-A Affinity Chromatography
    Immunogen
    Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA.
    Clone
    MEM-229
    Isotype
    IgG2a
    Top Product
    Discover our top product ENG Primary Antibody
  • Application Notes
    Flow Cytometry: 10 μg/mLPositive Control: Kg1 Human acute myelogenous leukemia cell lineWestern Blotting (Non-Reducing Conditions).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH ~7.4, 15 mM Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Koch, Staffler, Hüttinger, Hilgert, Prager, Cerný, Steinlein, Majdic, Horejsí, Stockinger: "T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density." in: International immunology, Vol. 11, Issue 5, pp. 777-86, (1999) (PubMed).

  • Target
    Endoglin (ENG)
    Alternative Name
    CD105 / Endoglin (ENG Products)
    Synonyms
    ENG antibody, MGC137842 antibody, DKFZp469D0419 antibody, END antibody, HHT1 antibody, ORW1 antibody, AI528660 antibody, AI662476 antibody, CD105 antibody, S-endoglin antibody, endoglin antibody, ENG antibody, Eng antibody
    Background
    CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.Synonyms: END, ENG, HHT1, ORW, ORW1
    UniProt
    P17813
You are here:
Support