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SOS1 antibody

SOS1 Reactivity: Human, Mouse WB, IF, EIA Host: Mouse Monoclonal SOS-1 unconjugated
Catalog No. ABIN238504
  • Target See all SOS1 Antibodies
    SOS1 (Son of Sevenless Homolog 1 (SOS1))
    Reactivity
    • 25
    • 10
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 18
    • 9
    • 1
    Mouse
    Clonality
    • 19
    • 9
    Monoclonal
    Conjugate
    • 25
    • 1
    • 1
    • 1
    This SOS1 antibody is un-conjugated
    Application
    • 20
    • 14
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein.
    Characteristics
    Synonyms: SOS-1, Son of sevenless homolog 1
    Purification
    Protein A affinity chromatography.
    Immunogen
    Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
    Clone
    SOS-1
    Isotype
    IgG1
  • Application Notes
    Western Blotting under reducing conditions (1 μg/mL): Positive control: HeLa human cervix carcinoma cell line. Immunocytochemistry. ELISA.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4 with 15 mM sodium azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
    Shelf life: One year from despatch.
    Expiry Date
    12 months
  • Target
    SOS1 (Son of Sevenless Homolog 1 (SOS1))
    Alternative Name
    SOS1 (SOS1 Products)
    Synonyms
    GF1 antibody, GGF1 antibody, GINGF antibody, HGF antibody, NS4 antibody, 4430401P03Rik antibody, 9630010N06 antibody, AI449023 antibody, SOS Ras/Rac guanine nucleotide exchange factor 1 antibody, son of sevenless homolog 1 (Drosophila) antibody, SOS1 antibody, Sos1 antibody
    Target Type
    Viral Protein
    Background
    The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.Synonyms: SOS-1, Son of sevenless homolog 1
    Gene ID
    6654
    UniProt
    Q07889
    Pathways
    RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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