COX11 antibody

Catalog No. ABIN2427991

Product Details anti-COX11 Antibody

Target: COX11 (COX11 Cytochrome C Oxidase Assembly (COX11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX11 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human COX11

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:5000, IHC 1:25-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COX11

Target: COX11 (COX11 Cytochrome C Oxidase Assembly (COX11))

Alternative Name: COX11 (COX11 Products)

Synonyms: COX11P antibody, im:6904550 antibody, zgc:162286 antibody, 2010004I09Rik antibody, COX11 antibody, COX11, cytochrome c oxidase copper chaperone antibody, cytochrome c oxidase assembly homolog 11 (yeast) antibody, cytochrome c oxidase assembly protein 11 antibody, COX11 cytochrome c oxidase assembly homolog (yeast) antibody, cytochrome c oxidase assembly protein antibody, COX11, cytochrome c oxidase copper chaperone pseudogene 1 antibody, COX11 cytochrome c oxidase copper chaperone antibody, COX11 antibody, cox11 antibody, Cox11 antibody, COX11P1 antibody

Background: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.

Molecular Weight: Calculated MW: 31 kDa

Pathways: Regulation of Carbohydrate Metabolic Process