Importin 4 antibody

Catalog No. ABIN2430313

Product Details anti-Importin 4 Antibody

Target: Importin 4 (IPO4)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Affinity purification

Immunogen: Recombinant protein of human IPO4

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Importin 4

Target: Importin 4 (IPO4)

Alternative Name: IPO4 (IPO4 Products)

Synonyms: Imp4 antibody, 8430408O15Rik antibody, AA409693 antibody, Imp4a antibody, RanBP4 antibody, importin 4 antibody, IPO4 antibody, Ipo4 antibody

Background: Importin-4is aproteinthat in humans is encoded by theIPO4gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

Molecular Weight: Calculated MW: 119 kDa

Pathways: Protein targeting to Nucleus