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SPAG1 antibody

SPAG1 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2431845
  • Target See all SPAG1 Antibodies
    SPAG1 (Sperm Associated Antigen 1 (SPAG1))
    Reactivity
    • 30
    • 1
    • 1
    • 1
    Human
    Host
    • 29
    • 1
    Rabbit
    Clonality
    • 30
    Polyclonal
    Conjugate
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPAG1 antibody is un-conjugated
    Application
    • 22
    • 16
    • 16
    • 2
    • 1
    Western Blotting (WB), ELISA
    Purification
    Affinity purification
    Immunogen
    Synthetic peptide of human SPAG1
    Isotype
    IgG
    Top Product
    Discover our top product SPAG1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.3 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    Preservative
    Sodium azide
    Handling Advice
    Avoid freeze / thaw cycles.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SPAG1 (Sperm Associated Antigen 1 (SPAG1))
    Alternative Name
    SPAG1 (SPAG1 Products)
    Synonyms
    cb1089 antibody, MGC162178 antibody, wu:fj78g10 antibody, sp75 antibody, tpis antibody, hsd-3.8 antibody, HSD-3.8 antibody, SP75 antibody, TPIS antibody, sperm associated antigen 1 antibody, sperm associated antigen 1a antibody, SPAG1 antibody, spag1a antibody, CpipJ_CPIJ006297 antibody, spag1 antibody, Spag1 antibody
    Background
    The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
    Molecular Weight
    Calculated MW: 104 kDa
    NCBI Accession
    NP_003105
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