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ATF6 antibody (N-Term)

ATF6 Reactivity: Human, Mouse WB, IP Host: Mouse Monoclonal 37-1 unconjugated
Catalog No. ABIN2451923
  • Target See all ATF6 Antibodies
    ATF6 (Activating Transcription Factor 6 (ATF6))
    Binding Specificity
    • 16
    • 15
    • 12
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 84
    • 43
    • 32
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Human, Mouse
    Host
    • 73
    • 11
    • 1
    Mouse
    Clonality
    • 75
    • 10
    Monoclonal
    Conjugate
    • 46
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This ATF6 antibody is un-conjugated
    Application
    • 76
    • 27
    • 27
    • 24
    • 16
    • 16
    • 15
    • 11
    • 7
    • 6
    • 6
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Specificity
    Reactive to human and mouse ATF6alpha. However, clone 1-7 antibody is recommended for human cells.
    Characteristics
    The antibody was produced from hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.
    Purification
    Purified
    Sterility
    Sterile filtered
    Immunogen
    Recombinant ATF6alpha (amino-terminal fragment of ATF6alpha fused to GST)
    Clone
    37-1
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product ATF6 Primary Antibody
  • Application Notes
    1. Western blotting
    2. Immunoprecipitation (IP) (less efficient than clone1-7)
    This antibody does not work for immunofluorescence analyses.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 50 % Glycerol
    Preservative
    Azide free
    Storage
    -20 °C
  • Mori: "Divest yourself of a preconceived idea: transcription factor ATF6 is not a soluble protein!" in: Molecular biology of the cell, Vol. 21, Issue 9, pp. 1435-8, (2010) (PubMed).

    Yamamoto, Sato, Matsui, Sato, Okada, Yoshida, Harada, Mori: "Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1." in: Developmental cell, Vol. 13, Issue 3, pp. 365-76, (2007) (PubMed).

    Hai, Liu, Coukos, Green: "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers." in: Genes & development, Vol. 3, Issue 12B, pp. 2083-90, (1990) (PubMed).

  • Target
    ATF6 (Activating Transcription Factor 6 (ATF6))
    Alternative Name
    ATF6 alpha (ATF6 Products)
    Synonyms
    ATF-6-like antibody, GB16435 antibody, ATF6 antibody, Atf6 antibody, ATF6A antibody, 9130025P16Rik antibody, 9630036G24 antibody, AA789574 antibody, Atf6alpha antibody, ESTM49 antibody, activating transcription factor 6 antibody, uncharacterized LOC412432 antibody, activating transcription factor 6 S homeolog antibody, cyclic AMP-dependent transcription factor ATF-6 alpha antibody, ATF6 antibody, LOC412432 antibody, atf6.S antibody, LOC100122162 antibody, Atf6 antibody
    Background
    ATF6 (activating transcription factor 6) is an endoplasmic reticulum (ER) membrane-bound transcription factor activated in response to ER stress. When unfolded proteins accumulate in the ER, ATF6 is cleaved by regulated intramembrane proteolysis. The resulting amino-terminal fragment translocates to the nucleus and activates transcription by binding to ER stress-response elements present in the promoter regions of ER stress-inducible genes including those encoding ER chaperones and components of ER-associated degradation. The mammalian ATF6 family consists of two closely related homologs, ATF6alpha and ATF6beta. ATF6alpha but not ATF6beta plays a pivotal role in transcriptional control. The monoclonal antibody was characterized in the laboratory of Professor Kazutoshi Mori of Kyoto University.
    UniProt
    P18850
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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