TIH1 antibody, Tih1 antibody, si:dz182n13.5 antibody, zgc:92333 antibody, pleckstrin homology like domain family A member 3 antibody, pleckstrin homology like domain, family A, member 3 antibody, pleckstrin homology-like domain, family A, member 3 antibody, PHLDA3 antibody, Phlda3 antibody, phlda3 antibody
Background
PHLDA3 (Pleckstrin homology-like domain family A member 3) is a small PH (Pleckstrin homology) domain-only protein (127 a.a. in human) that is highly conserved in vertebrates. Recently PHLDA3 was found to be a p53-regulated repressor of Akt hence it is speculated as a tumor suppressor. PHLDA3 also inhibits anchorage-independent cell growth. PHLDA3 gene is frequently lost in human lung endocrine tumors.