RRM2 antibody (C-Term)

Catalog No. ABIN2452118

Product Details anti-RRM2 Antibody

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity (Details): Not tested in other species.

Purification: Affinity-purified with the immunogen peptide

Sterility: Sterile filtered

Immunogen: C-terminal peptide of Human and Mouse RRM2, C-TENSFTLDADF, conjugated with KLH

Application Details

Application Notes: 1) Western blotting: ~ 1/1,000 dilution
Not tested for other applications

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS (x1), 50 % glycerol. Azide and carrier free.

Preservative: Azide free

Storage: -20 °C

Storage Comment: Upon receipt aliquot and store at -20 C

References for anti-RRM2 antibody (ABIN2452118)

Takada, Shibata, Hiraoka, Masuda: "Identification of ribonucleotide reductase protein R1 as an activator of microtubule nucleation in Xenopus egg mitotic extracts." in: Molecular biology of the cell, Vol. 11, Issue 12, pp. 4173-87, (2000) (PubMed).

Target Details for RRM2

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Alternative Name: RRM2 / RNR-R2 (RRM2 Products)

Synonyms: R2 antibody, RR2 antibody, RR2M antibody, AA407299 antibody, rrm2 antibody, rr2m antibody, cb111 antibody, chunp6884 antibody, r2 antibody, ribonucleotide reductase regulatory subunit M2 antibody, ribonucleotide reductase M2 antibody, ribonucleotide reductase M2, gene 2 L homeolog antibody, ribonucleotide reductase M2, gene 1 antibody, ribonucleotide reductase M2 polypeptide antibody, RRM2 antibody, Rrm2 antibody, rrm2.2.L antibody, rrm2.1 antibody, rrm2 antibody

Background: Betag Ribonucleoside-diphosphate reductase subunit M2 (RRM2, 389 aa, 45 kDa) also known as ribonucleotide reductase subunit R2 (RNR-R2), is a rate-limiting subunit of an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. Deoxyribonucleotides in turn are used in the synthesis of DNA. The reaction catalyzed by RNR is strictly conserved in all living organisms. Furthermore RNR plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair.

UniProt: P31350

Pathways: Mitotic G1-G1/S Phases