GBA3 antibody (AA 1-150, AA 370-469)

Catalog No. ABIN2719172

Product Details anti-GBA3 Antibody

Target: GBA3 (Glucosidase, Beta, Acid 3 (Cytosolic) (GBA3))

Binding Specificity: AA 1-150, AA 370-469

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GBA3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Characteristics: Homo sapiens glucosidase, beta, acid 3 (cytosolic) (GBA3), transcript variant 1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Human recombinant protein fragment corresponding to amino acids 1-150 and AA 370-469 of human GBA3 (NP_066024) produced in E.coli.

Clone: 4F10

Isotype: IgG2b

Application Details

Application Notes: WB 1:500~2000, FLOW 1:100

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for GBA3

Target: GBA3 (Glucosidase, Beta, Acid 3 (Cytosolic) (GBA3))

Alternative Name: GBA3 (GBA3 Products)

Synonyms: im:6912508 antibody, CBG antibody, CBGL1 antibody, GLUC antibody, KLRP antibody, glucosylceramidase beta 3 antibody, glucosidase, beta, acid 3 (gene/pseudogene) antibody, glucosidase, beta, acid 3 (cytosolic) antibody, cytosolic beta-glucosidase antibody, glucosylceramidase beta 3 (gene/pseudogene) antibody, Gba3 antibody, gba3 antibody, GBA3 antibody, LOC100344458 antibody

Background: GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]). GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]).

Molecular Weight: 53.5 kDa

Gene ID: 57733

NCBI Accession: NM_020973

HGNC: 57733