ZFPM1 antibody

Catalog No. ABIN2457936

Product Details anti-ZFPM1 Antibody

Target: ZFPM1 (Zinc Finger Protein, Multitype 1 (ZFPM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFPM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZFPM1.

Application Details

Application Notes: ZFPM1 antibody can be used for detection of ZFPM1 by ELISA at 1:62500. ZFPM1 antibody can be used for detection of ZFPM1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store ZFPM1 antibody at -20 °C.

Target Details for ZFPM1

Target: ZFPM1 (Zinc Finger Protein, Multitype 1 (ZFPM1))

Alternative Name: ZFPM1 (ZFPM1 Products)

Synonyms: FOG antibody, FOG1 antibody, ZC2HC11A antibody, ZNF408 antibody, ZNF89A antibody, Fog1 antibody, Xfog antibody, fog antibody, fog-1 antibody, fog1 antibody, FOG-1 antibody, si:dkey-20g6.1 antibody, si:dkey-38l12.1 antibody, ZNF469 antibody, ZFPM1 antibody, zinc finger protein, FOG family member 1 antibody, zinc finger protein, multitype 1 antibody, zinc finger protein, FOG family member 1 L homeolog antibody, ZFPM1 antibody, Zfpm1 antibody, zfpm1.L antibody, zfpm1 antibody

Background: ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.

Molecular Weight: 105 kDa

Gene ID: 161882

NCBI Accession: NP_722520

UniProt: Q8IX07