KIF2A antibody

Catalog No. ABIN2458064

Product Details anti-KIF2A Antibody

Target: KIF2A (Kinesin Heavy Chain Member 2A (KIF2A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIF2A antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KIF2A.

Application Details

Application Notes: KIF2A antibody can be used for detection of KIF2A by ELISA at 1:62500. KIF2A antibody can be used for detection of KIF2A by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store KIF2A antibody at -20 °C.

Target Details for KIF2A

Target: KIF2A (Kinesin Heavy Chain Member 2A (KIF2A))

Alternative Name: KIF2A (KIF2A Products)

Synonyms: HK2 antibody, KIF2 antibody, C530030B14Rik antibody, Kif2 antibody, Kns2 antibody, M-kinesin antibody, kif2-a antibody, fj55b02 antibody, wu:fj55b02 antibody, kinesin family member 2A antibody, kinesin heavy chain member 2A L homeolog antibody, kinesin heavy chain member 2A antibody, zgc:103670 antibody, Kinesin-2 antibody, KIF2A antibody, Kif2a antibody, kif2a.L antibody, zgc:103670 antibody, GL50803_17333 antibody, GL50803_16456 antibody

Background: KIF2A belongs to the kinesin-like protein family, MCAK/KIF2 subfamily. It contains 1 kinesin-motor domain. KIF2A plus end-directed microtubule-dependent motor required for normal brain development. It may regulate microtubule dynamics during axonal growth. KIF2A is implicated in formation of bipolar mitotic spindles. It has microtubule depolymerization activity. Hela cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.

Molecular Weight: 80 kDa

Gene ID: 3796

NCBI Accession: NP_004511

UniProt: O00139

Pathways: Microtubule Dynamics, Ribonucleoprotein Complex Subunit Organization