Snurportin 1 antibody

Catalog No. ABIN2458516

Product Details anti-Snurportin 1 Antibody

Target: Snurportin 1 (SNUPN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Snurportin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SNUPN.

Application Details

Application Notes: SNUPN antibody can be used for detection of SNUPN by ELISA at 1:62500. SNUPN antibody can be used for detection of SNUPN by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SNUPN antibody at -20 °C.

Target Details for Snurportin 1

Target: Snurportin 1 (SNUPN)

Alternative Name: SNUPN (SNUPN Products)

Synonyms: rnut1 antibody, zgc:77819 antibody, wu:fc41a03 antibody, SNUPN antibody, kpnbl antibody, snurportin1 antibody, KPNBL antibody, RNUT1 antibody, Snurportin1 antibody, 0610031A09Rik antibody, Rnut1 antibody, Snupn1 antibody, snurportin 1 antibody, snupn antibody, SNUPN antibody, Snupn antibody

Background: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. SNUPN interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor.The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.

Molecular Weight: 41 kDa

Gene ID: 10073

NCBI Accession: NP_005692

UniProt: O95149

Pathways: Ribonucleoprotein Complex Subunit Organization, Protein targeting to Nucleus