TPM3 antibody

Catalog No. ABIN2458556

Product Details anti-TPM3 Antibody

Target: TPM3 (Tropomyosin 3 (TPM3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPM3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TPM3.

Application Details

Application Notes: TPM3 antibody can be used for detection of TPM3 by ELISA at 1:312500. TPM3 antibody can be used for detection of TPM3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store TPM3 antibody at -20 °C.

Target Details for TPM3

Target: TPM3 (Tropomyosin 3 (TPM3))

Alternative Name: TPM3 (TPM3 Products)

Synonyms: CAPM1 antibody, CFTD antibody, NEM1 antibody, OK/SW-cl.5 antibody, TM-5 antibody, TM3 antibody, TM30 antibody, TM30nm antibody, TM5 antibody, TPMsk3 antibody, TRK antibody, hscp30 antibody, cb674 antibody, fa17b11 antibody, fb83b01 antibody, fk41e01 antibody, hm:zeh0298 antibody, wu:fa17b11 antibody, wu:fb83b01 antibody, wu:fk41e01 antibody, zeh0298 antibody, zgc:77592 antibody, TPM3 antibody, Tm5NM antibody, Tpm-5 antibody, Tpm5 antibody, Trop-5 antibody, gamma-TM antibody, hTM30nm antibody, hTMnm antibody, tm3 antibody, tpm3 antibody, tpm3.L antibody, tropomyosin 3 antibody, tropomyosin 3, gamma antibody, tropomyosin 3 S homeolog antibody, TPM3 antibody, tpm3 antibody, Tpm3 antibody, tpm3.S antibody

Background: TPM3 is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer.This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 33 kDa

Gene ID: 7170

NCBI Accession: NP_705935

UniProt: P06753