DNASE2B antibody

Catalog No. ABIN2458669

Product Details anti-DNASE2B Antibody

Target: DNASE2B (Deoxyribonuclease II beta (DNASE2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNASE2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DNASE2B.

Application Details

Application Notes: DNASE2B antibody can be used for detection of DNASE2B by ELISA at 1:1562500. DNASE2B antibody can be used for detection of DNASE2B by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store DNASE2B antibody at -20 °C.

Target Details for DNASE2B

Target: DNASE2B (Deoxyribonuclease II beta (DNASE2B))

Alternative Name: DNASE2B (DNASE2B Products)

Synonyms: DNASE2 antibody, deoxyribonuclease-2-beta antibody, DLAD antibody, DNASE2B antibody, dnase2b antibody, AI526873 antibody, Dlad antibody, DnaseIIb antibody, UOX antibody, deoxyribonuclease 2 beta antibody, deoxyribonuclease II beta antibody, DNASE2B antibody, dnase2b antibody, Dnase2b antibody

Background: DNASE2B shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH . Unlike DNase II which is ubiquitously expressed, expression of this protein is restricted to the salivary gland and lungs. The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH . Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 39 kDa

Gene ID: 58511

NCBI Accession: NP_067056

UniProt: Q8WZ79