LIN7C antibody

Catalog No. ABIN2458686

Product Details anti-LIN7C Antibody

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIN7C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human LIN7C.

Application Details

Application Notes: LIN7C antibody can be used for detection of LIN7C by ELISA at 1:312500. LIN7C antibody can be used for detection of LIN7C by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store LIN7C antibody at -20 °C.

Target Details for LIN7C

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Alternative Name: LIN7C (LIN7C Products)

Synonyms: LIN7C antibody, fb75b09 antibody, wu:fb75b09 antibody, zgc:101881 antibody, LIN-7-C antibody, LIN-7C antibody, MALS-3 antibody, MALS3 antibody, VELI3 antibody, 9130007B12Rik antibody, AI303698 antibody, AU019331 antibody, AW125731 antibody, D2Ertd520e antibody, Veli3 antibody, lin-7 homolog C, crumbs cell polarity complex component antibody, lin-7 homolog C L homeolog antibody, lin-7 homolog C (C. elegans) antibody, LIN7C antibody, lin7c.L antibody, lin7c antibody, Lin7c antibody

Background: LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Molecular Weight: 22 kDa

Gene ID: 55327

NCBI Accession: NP_060832

UniProt: Q9NUP9

Pathways: Synaptic Membrane