ATP2B4 antibody

Catalog No. ABIN2458841

Product Details anti-ATP2B4 Antibody

Target: ATP2B4 (ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP2B4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ATP2B4.

Application Details

Application Notes: ATP2B4 antibody can be used for detection of ATP2B4 by ELISA at 1:1562500. ATP2B4 antibody can be used for detection of ATP2B4 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store ATP2B4 antibody at -20 °C.

Target Details for ATP2B4

Target: ATP2B4 (ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4))

Alternative Name: ATP2B4 (ATP2B4 Products)

Synonyms: ATP2B2 antibody, MXRA1 antibody, PMCA4 antibody, PMCA4b antibody, PMCA4x antibody, atp2b2 antibody, atp2b3 antibody, mxra1 antibody, pmca4 antibody, pmca4b antibody, pmca4x antibody, zgc:152801 antibody, ATP2B4 antibody, ATP2B1 antibody, Pmca4 antibody, ATPase plasma membrane Ca2+ transporting 4 antibody, ATPase, Ca++ transporting, plasma membrane 4 L homeolog antibody, ATPase, Ca++ transporting, plasma membrane 4 antibody, ATP2B4 antibody, atp2b4.L antibody, atp2b4 antibody, Atp2b4 antibody

Background: ATP2B4 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. ATP2B4 is the plasma membrane calcium ATPase isoform 4.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 129 kDa

Gene ID: 493

NCBI Accession: NP_001001396

UniProt: B1APW5

Pathways: Ribonucleoside Biosynthetic Process