Transferrin Receptor 2 antibody

Catalog No. ABIN2458932

Product Details anti-Transferrin Receptor 2 Antibody

Target: Transferrin Receptor 2 (TFR2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transferrin Receptor 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TFR2.

Application Details

Application Notes: TFR2 antibody can be used for detection of TFR2 by ELISA at 1:62500. TFR2 antibody can be used for detection of TFR2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store TFR2 antibody at -20 °C.

Target Details for Transferrin Receptor 2

Target: Transferrin Receptor 2 (TFR2)

Alternative Name: TFR2 (TFR2 Products)

Synonyms: TFR2 antibody, Trfr2 antibody, HFE3 antibody, TFRC2 antibody, zgc:123043 antibody, transferrin receptor 2 antibody, TFR2 antibody, Tfr2 antibody, tfr2 antibody

Background: TFR2,a member of the transferrin receptor-like family,is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III.This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 89 kDa

Gene ID: 7036

NCBI Accession: NP_003218

UniProt: Q9UP52

Pathways: Transition Metal Ion Homeostasis