MMP20 antibody

Catalog No. ABIN2459028

Product Details anti-MMP20 Antibody

Target: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP20 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MMP20.

Application Details

Application Notes: MMP20 antibody can be used for detection of MMP20 by ELISA at 1:312500. MMP20 antibody can be used for detection of MMP20 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store MMP20 antibody at -20 °C.

Target Details for MMP20

Target: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Alternative Name: MMP20 (MMP20 Products)

Synonyms: AI2A2 antibody, MMP-20 antibody, MMP25 antibody, MMP20 antibody, mmp20 antibody, matrix metallopeptidase 20 antibody, matrix metallopeptidase 20 L homeolog antibody, matrix metallopeptidase 20 (enamelysin) antibody, MMP20 antibody, mmp20.L antibody, Mmp20 antibody

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP20 degrades amelogenin, the major protein component of dental enamel matrix, and so the protein is thought to play a role in tooth enamel formation. A mutation in the gene encoding MMP20, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and so the protein is thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes that localizes to chromosome 11q22.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 43 kDa

Gene ID: 9313

NCBI Accession: NP_004762

UniProt: O60882