SPTLC2 antibody

Catalog No. ABIN2459217

Product Details anti-SPTLC2 Antibody

Target: SPTLC2 (serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTLC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SPTLC2.

Application Details

Application Notes: SPTLC2 antibody can be used for detection of SPTLC2 by ELISA at 1:312500. SPTLC2 antibody can be used for detection of SPTLC2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SPTLC2 antibody at -20 °C.

Target Details for SPTLC2

Target: SPTLC2 (serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2))

Alternative Name: SPTLC2 (SPTLC2 Products)

Synonyms: HSN1C antibody, LCB2 antibody, LCB2A antibody, NSAN1C antibody, SPT2 antibody, hLCB2a antibody, sptlc2 antibody, zgc:110661 antibody, AI173915 antibody, mKIAA0526 antibody, Pomt2 antibody, LCB2a antibody, SPTLC2 antibody, serine palmitoyltransferase long chain base subunit 2 antibody, serine palmitoyltransferase 2 antibody, serine palmitoyltransferase, long chain base subunit 2 S homeolog antibody, serine palmitoyltransferase, long chain base subunit 2a antibody, serine palmitoyltransferase, long chain base subunit 2 antibody, SPTLC2 antibody, LOC100446763 antibody, sptlc2 antibody, sptlc2.S antibody, sptlc2a antibody, Sptlc2 antibody

Background: SPTLC2 is a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.

Molecular Weight: 63 kDa

Gene ID: 9517

NCBI Accession: NP_004854

UniProt: O15270