HMBS antibody

Catalog No. ABIN2459756

Product Details anti-HMBS Antibody

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMBS antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HMBS.

Application Details

Application Notes: HMBS antibody can be used for detection of HMBS by ELISA at 1:312500. HMBS antibody can be used for detection of HMBS by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store HMBS antibody at -20 °C.

Target Details for HMBS

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Alternative Name: HMBS (HMBS Products)

Synonyms: PBG-D antibody, PBGD antibody, PORC antibody, UPS antibody, URO-S antibody, hemC antibody, pbg-d antibody, pbgd antibody, ups antibody, SPAC806.01 antibody, DDBDRAFT_0186148 antibody, DDBDRAFT_0231417 antibody, DDB_0186148 antibody, DDB_0231417 antibody, Hmbs antibody, NV50236 antibody, T25658 antibody, Ups antibody, Uros1 antibody, hmbs antibody, zgc:64128 antibody, hmbsl antibody, id:ibd5004 antibody, im:7140060 antibody, zgc:110690 antibody, hydroxymethylbilane synthase antibody, hydroxymethylbilane synthase S homeolog antibody, hydroxymethylbilane synthase L homeolog antibody, hydroxymethylbilane synthase (predicted) antibody, Hydroxymethylbilane synthase antibody, hydroxymethylbilane synthase a antibody, hydroxymethylbilane synthase, b antibody, HMBS antibody, Hmbs antibody, hmbs antibody, hmbs.2.S antibody, hmbs.L antibody, CNC02250 antibody, hem3 antibody, hemC antibody, Trad_0335 antibody, Plabr_2100 antibody, Sgly_3113 antibody, SMLT_RS19660 antibody, PMI_RS16580 antibody, hmbsa antibody, hmbsb antibody

Background: HMBS is a member of the hydroxymethylbilane synthase superfamily. It is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria.This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

Molecular Weight: 40 kDa

Gene ID: 3145

NCBI Accession: NP_000181

UniProt: P08397