KAT2B antibody

Catalog No. ABIN2460477

Product Details anti-KAT2B Antibody

Target: KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))

Reactivity: Human, Mouse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KAT2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PCAF.

Application Details

Application Notes: PCAF antibody can be used for detection of PCAF by ELISA at 1:62500. PCAF antibody can be used for detection of PCAF by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PCAF antibody at -20 °C.

Target Details for KAT2B

Target: KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))

Alternative Name: PCAF (KAT2B Products)

Synonyms: PCAF antibody, pcaf antibody, si:ch211-1j13.2 antibody, zgc:161980 antibody, gb:dq017634 antibody, im:7156024 antibody, CAF antibody, P antibody, P/CAF antibody, A930006P13Rik antibody, AI461839 antibody, AW536563 antibody, Pcaf antibody, p/CAF antibody, lysine acetyltransferase 2B antibody, K(lysine) acetyltransferase 2B antibody, K(lysine) acetyltransferase 2A antibody, KAT2B antibody, kat2b antibody, kat2a antibody, Kat2b antibody

Background: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.

Molecular Weight: 93 kDa

Gene ID: 8850

NCBI Accession: NP_003875

UniProt: Q92831

Pathways: p53 Signaling, Regulation of Carbohydrate Metabolic Process