POU4F3 antibody
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- Target See all POU4F3 Antibodies
- POU4F3 (POU Domain, Class 4, Transcription Factor 3 (POU4F3))
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Reactivity
- Human, Mouse, Rat, Dog, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This POU4F3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Purification
- Antibody is purified by protein A chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human POU4F3.
- Top Product
- Discover our top product POU4F3 Primary Antibody
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- Application Notes
- POU4F3 antibody can be used for detection of POU4F3 by ELISA at 1:312500. POU4F3 antibody can be used for detection of POU4F3 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handling Advice
- As with any antibody avoid repeat freeze-thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store POU4F3 antibody at -20 °C.
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- Target
- POU4F3 (POU Domain, Class 4, Transcription Factor 3 (POU4F3))
- Alternative Name
- POU4F3 (POU4F3 Products)
- Synonyms
- POU4F3 antibody, BRN-3 antibody, BRN3 antibody, BRN3C antibody, DFNA15 antibody, BRN-3.1 antibody, brn-3c antibody, brn3.1 antibody, brn3c antibody, Brn3.1 antibody, Brn3c antibody, ddl antibody, dreidel antibody, POU class 4 homeobox 3 antibody, POU domain, class 4, transcription factor 3 antibody, POU4F3 antibody, Pou4f3 antibody, pou4f3 antibody
- Background
- POU4F3 is capable of activating both BDNF and NT-3 promoters in inner ear sensory epithelial cell lines. Mutant POU4F3 loses most of its transcriptional activity and most of its ability to bind to DNA. The mutation causes autosomal-dominant nonsyndromic hearing loss and eventually leads to hair cell morbidity in affected family members.
- Molecular Weight
- 37 kDa
- Gene ID
- 5459
- NCBI Accession
- NP_002691
- UniProt
- Q15319
- Pathways
- Sensory Perception of Sound
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