MIER1 antibody

Catalog No. ABIN2460961

Product Details anti-MIER1 Antibody

Target: MIER1 (Mesoderm Induction Early Response 1 (MIER1))

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIER1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MIER1.

Application Details

Application Notes: MIER1 antibody can be used for detection of MIER1 by ELISA at 1:312500. MIER1 antibody can be used for detection of MIER1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store MIER1 antibody at -20 °C.

Target Details for MIER1

Target: MIER1 (Mesoderm Induction Early Response 1 (MIER1))

Alternative Name: MIER1 (MIER1 Products)

Synonyms: 4933425I22Rik antibody, 5830411K19Rik antibody, mKIAA1610 antibody, mier1 antibody, wu:fb30a02 antibody, zgc:56179 antibody, mi-er1 antibody, ER1 antibody, MI-ER1 antibody, RGD1562337 antibody, MEIR1 treanscription regulator antibody, MIER1 transcriptional regulator antibody, mesoderm induction early response 1a, transcriptional regulator antibody, mesoderm induction early response 1, transcriptional regulator L homeolog antibody, Mier1 antibody, MIER1 antibody, mier1a antibody, mier1.L antibody

Background: The association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters. Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function in the regulation of transcription. Repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).

Molecular Weight: 49 kDa

Gene ID: 57708

NCBI Accession: NP_065999

UniProt: Q8NES5

Pathways: Chromatin Binding