ZIC2 antibody

Catalog No. ABIN2461223

Product Details anti-ZIC2 Antibody

Target: ZIC2

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZIC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZIC2.

Application Details

Application Notes: ZIC2 antibody can be used for detection of ZIC2 by ELISA at 1:62500. ZIC2 antibody can be used for detection of ZIC2 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store ZIC2 antibody at -20 °C.

Target Details for ZIC2

Target: ZIC2

Alternative Name: ZIC2 (ZIC2 Products)

Synonyms: HPE5 antibody, Ku antibody, cb851 antibody, fb26a03 antibody, wu:fb26a03 antibody, zic2 antibody, zic2.1 antibody, hpe5 antibody, hm:zeh0655 antibody, id:ibd5017 antibody, zic2.2 antibody, zic2l antibody, Zic family member 2 antibody, zinc finger protein of the cerebellum 2 antibody, zic family member 2 (odd-paired homolog, Drosophila), a antibody, Zic family member 2 L homeolog antibody, zic family member 2 (odd-paired homolog, Drosophila) b antibody, ZIC2 antibody, Zic2 antibody, zic2a antibody, zic2.L antibody, zic2b antibody

Background: ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.

Molecular Weight: 55 kDa

Gene ID: 7546

NCBI Accession: NP_009060

UniProt: O95409

Pathways: Tube Formation