DMAP1 antibody

Catalog No. ABIN2461898

Product Details anti-DMAP1 Antibody

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DMAP1.

Application Details

Application Notes: DMAP1 antibody can be used for detection of DMAP1 by ELISA at 1:1562500. DMAP1 antibody can be used for detection of DMAP1 by western blot at 5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store DMAP1 antibody at -20 °C.

Target Details for DMAP1

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Alternative Name: DMAP1 (DMAP1 Products)

Synonyms: Afu4g07380 antibody, T8I13.5 antibody, DNMAP1 antibody, DNMTAP1 antibody, EAF2 antibody, MEAF2 antibody, SWC4 antibody, zgc:55593 antibody, dnmap1 antibody, dnmtap1 antibody, eaf2 antibody, meaf2 antibody, swc4 antibody, 1500016M21Rik antibody, Dmtap1 antibody, mKIAA1425 antibody, DNA methyltransferase 1-associated protein DMAP1 antibody, DNA methyltransferase 1-associated protein 1 antibody, DNA methyltransferase 1 associated protein 1 antibody, myb-like transcription factor family protein antibody, DNA methyltransferase 1 associated protein 1 L homeolog antibody, AFUA_4G07380 antibody, NFIA_108840 antibody, ACLA_046700 antibody, CpipJ_CPIJ017959 antibody, Bm1_47540 antibody, PMAA_026820 antibody, AFLA_112450 antibody, TSTA_072020 antibody, BDBG_02603 antibody, AT2G47210 antibody, CpipJ_CPIJ007438 antibody, DMAP1 antibody, dmap1 antibody, dmap1.L antibody, Dmap1 antibody

Background: DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

Molecular Weight: 53 kDa

Gene ID: 55929

NCBI Accession: NP_061973

UniProt: Q9NPF5