PRDM12 antibody

Catalog No. ABIN2461913

Product Details anti-PRDM12 Antibody

Target: PRDM12 (PR Domain Containing 12 (PRDM12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PRDM12.

Application Details

Application Notes: PRDM12 antibody can be used for detection of PRDM12 by ELISA at 1:62500. PRDM12 antibody can be used for detection of PRDM12 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PRDM12 antibody at -20 °C.

Target Details for PRDM12

Target: PRDM12 (PR Domain Containing 12 (PRDM12))

Alternative Name: PRDM12 (PRDM12 Products)

Synonyms: PRDM12 antibody, prdm12 antibody, MGC146714 antibody, PFM9 antibody, pfm9 antibody, Gm998 antibody, PR/SET domain 12 antibody, PR domain containing 12 antibody, PR domain containing 12 L homeolog antibody, PR domain containing 12a antibody, PRDM12 antibody, prdm12 antibody, prdm12.L antibody, Prdm12 antibody, prdm12a antibody

Background: PRDM12 belongs to PR-domain family which are involved in human cancers in an unusual yin-yang fashion. Two products are normally produced from a PR-domain family member which differ by the presence or absence of the PR domain, the PR-plus product is disrupted or underexpressed whereas the PR-minus product is present or overexpressed in cancer cells. This imbalance in the amount of the two products, a result of either genetic or epigenetic events, appears to be an important cause of malignancy. PRDM12 may have a potential role in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion.

Molecular Weight: 40 kDa

Gene ID: 59335

NCBI Accession: NP_067632

UniProt: Q9H4Q4