ZNF496 antibody

Catalog No. ABIN2461953

Product Details anti-ZNF496 Antibody

Target: ZNF496 (Zinc Finger Protein 496 (ZNF496))

Reactivity: Mouse, Human, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF496 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZNF496.

Application Details

Application Notes: ZNF496 antibody can be used for detection of ZNF496 by ELISA at 1:62500. ZNF496 antibody can be used for detection of ZNF496 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store ZNF496 antibody at -20 °C.

Target Details for ZNF496

Target: ZNF496 (Zinc Finger Protein 496 (ZNF496))

Alternative Name: ZNF496 (ZNF496 Products)

Synonyms: Zkscan17 antibody, Znf496 antibody, ZNF496 antibody, NIZP1 antibody, ZFP496 antibody, ZKSCAN17 antibody, ZSCAN49 antibody, BC040205 antibody, D130067D09 antibody, Nizp1 antibody, Zfp496 antibody, zinc finger protein 496 antibody, zinc finger with KRAB and SCAN domains 17 antibody, Zfp496 antibody, ZNF496 antibody, Zkscan17 antibody

Background: ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn (II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.

Molecular Weight: 67 kDa

Gene ID: 84838

NCBI Accession: NP_116141

UniProt: Q96IT1