EXOSC6 antibody

Catalog No. ABIN2462323

Product Details anti-EXOSC6 Antibody

Target: EXOSC6 (Exosome Component 6 (EXOSC6))

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human EXOSC6.

Application Details

Application Notes: EXOSC6 antibody can be used for detection of EXOSC6 by ELISA at 1:62500. EXOSC6 antibody can be used for detection of EXOSC6 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store EXOSC6 antibody at -20 °C.

Target Details for EXOSC6

Target: EXOSC6 (Exosome Component 6 (EXOSC6))

Alternative Name: EXOSC6 (EXOSC6 Products)

Synonyms: exosc6 antibody, RAR-gamma antibody, id:ibd1130 antibody, wu:fe17d05 antibody, zgc:110071 antibody, EAP4 antibody, MTR3 antibody, Mtr3p antibody, hMtr3p antibody, p11 antibody, 2610510N21Rik antibody, C76919 antibody, Mtr3 antibody, exosome component 6 antibody, EXOSC6 antibody, exosc6 antibody, CpipJ_CPIJ018071 antibody, Exosc6 antibody

Background: EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly (A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly (A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.

Molecular Weight: 30 kDa

Gene ID: 118460

NCBI Accession: NP_478126

UniProt: Q5RKV6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response