DCP2 antibody

Catalog No. ABIN2462345

Product Details anti-DCP2 Antibody

Target: DCP2 (DCP2 Decapping Enzyme Homolog (DCP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DCP2.

Application Details

Application Notes: DCP2 antibody can be used for detection of DCP2 by ELISA at 1:62500. DCP2 antibody can be used for detection of DCP2 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store DCP2 antibody at -20 °C.

Target Details for DCP2

Target: DCP2 (DCP2 Decapping Enzyme Homolog (DCP2))

Alternative Name: DCP2 (DCP2 Products)

Synonyms: DDBDRAFT_0185453 antibody, DDBDRAFT_0252811 antibody, DDB_0185453 antibody, DDB_0252811 antibody, 2410015D23Rik antibody, 5730537H01Rik antibody, AL118268 antibody, NUDT20 antibody, RGD1562909 antibody, mRNA-decapping enzyme 2 antibody, hypothetical protein antibody, decapping mRNA 2 antibody, CpipJ_CPIJ019463 antibody, PTRG_05936 antibody, dcp2 antibody, MCYG_05106 antibody, MGYG_07617 antibody, PGTG_03310 antibody, Tsp_04018 antibody, DCP2 antibody, Dcp2 antibody

Background: DCP2 is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. DCP2 removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. It has higher activity towards mRNAs that lack a poly (A) tail, but has no activity towards a cap structure lacking a RNA moiety.DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).

Molecular Weight: 48 kDa

Gene ID: 167227

NCBI Accession: NP_689837

UniProt: Q8IU60