GSTM2 antibody

Catalog No. ABIN2462480

Product Details anti-GSTM2 Antibody

Target: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GSTM2.

Application Details

Application Notes: GSTM2 antibody can be used for detection of GSTM2 by ELISA at 1:312500. GSTM2 antibody can be used for detection of GSTM2 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store GSTM2 antibody at -20 °C.

Target Details for GSTM2

Target: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Alternative Name: GSTM2 (GSTM2 Products)

Synonyms: GSTA4 antibody, GST4 antibody, GSTM antibody, GSTM2-2 antibody, GTHMUS antibody, Gstb-2 antibody, Gstb2 antibody, GSTIV antibody, glutathione S-transferase mu 2 antibody, glutathione S-transferase mu 2 (muscle) antibody, glutathione S-transferase Mu 2 antibody, glutathione S-transferase, mu 2 antibody, glutathione S-transferase 2 antibody, Glutathione S-transferase 4 antibody, Gstm2 antibody, GSTM2 antibody, LOC100732167 antibody, gst2 antibody, gst-4 antibody

Background: At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. GSTM2 is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

Molecular Weight: 26 kDa

Gene ID: 2946

NCBI Accession: NP_000839

UniProt: P28161

Pathways: Negative Regulation of Transporter Activity