PTPRR antibody

Catalog No. ABIN2462848

Product Details anti-PTPRR Antibody

Target: PTPRR (Protein tyrosine Phosphatase, Receptor Type, R (PTPRR))

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PTPRR.

Application Details

Application Notes: PTPRR antibody can be used for detection of PTPRR by ELISA at 1:62500. PTPRR antibody can be used for detection of PTPRR by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PTPRR antibody at -20 °C.

Target Details for PTPRR

Target: PTPRR (Protein tyrosine Phosphatase, Receptor Type, R (PTPRR))

Alternative Name: PTPRR (PTPRR Products)

Synonyms: EC-PTP antibody, PCPTP1 antibody, PTP-SL antibody, PTPBR7 antibody, PTPRQ antibody, Pcptp1 antibody, ec-ptp antibody, pcptp1 antibody, ptp-sl antibody, ptpbr7 antibody, PTPRR antibody, Gmcp1 antibody, RPTPRR antibody, mPTP213 antibody, protein tyrosine phosphatase, receptor type R antibody, protein tyrosine phosphatase, receptor type, R antibody, protein tyrosine phosphatase, receptor type R L homeolog antibody, protein tyrosine phosphatase, receptor type, r antibody, receptor-type tyrosine-protein phosphatase R antibody, PTPRR antibody, Ptprr antibody, ptprr.L antibody, ptprr antibody, LOC100715069 antibody

Background: PTPRR is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia.

Molecular Weight: 46 kDa, 74 kDa

Gene ID: 5801

NCBI Accession: NP_570897

UniProt: Q7Z2V8