SEPN1 antibody

Catalog No. ABIN2463087

Product Details anti-SEPN1 Antibody

Target: SEPN1 (Selenoprotein N, 1 (SEPN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEPN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SEPN1.

Application Details

Application Notes: SEPN1 antibody can be used for detection of SEPN1 by ELISA at 1:1562500. SEPN1 antibody can be used for detection of SEPN1 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SEPN1 antibody at -20 °C.

Target Details for SEPN1

Target: SEPN1 (Selenoprotein N, 1 (SEPN1))

Alternative Name: SEPN1 (SEPN1 Products)

Synonyms: CFTD antibody, MDRS1 antibody, RSMD1 antibody, RSS antibody, SELN antibody, 1110019I12Rik antibody, AI414492 antibody, SePN antibody, cb686 antibody, wu:fb06g01 antibody, wu:fb73d02 antibody, wu:fv41b08 antibody, zgc:101091 antibody, selenoprotein N antibody, SELENON antibody, Selenon antibody, selenon antibody

Background: SEPN1 is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Mutations in SEPN1 gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome.This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Molecular Weight: 58 kDa

Gene ID: 57190

NCBI Accession: NP_996809

Pathways: Skeletal Muscle Fiber Development