FDFT1 antibody

Catalog No. ABIN2463197

Product Details anti-FDFT1 Antibody

Target: FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FDFT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FDFT1.

Application Details

Application Notes: FDFT1 antibody can be used for detection of FDFT1 by ELISA at 1:12500. FDFT1 antibody can be used for detection of FDFT1 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store FDFT1 antibody at -20 °C.

Target Details for FDFT1

Target: FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1))

Alternative Name: FDFT1 (FDFT1 Products)

Synonyms: FDFT1 antibody, DKFZp459C1712 antibody, SQS antibody, SS antibody, DGPT antibody, ERG9 antibody, fdft1 antibody, farnesyl-diphosphate farnesyltransferase 1 antibody, squalene synthase antibody, farnesyl diphosphate farnesyl transferase 1 antibody, FDFT1 antibody, fdft1 antibody, LOC100560926 antibody, Fdft1 antibody

Background: FDFT1 is a membrane-associated enzyme located at a branch point in the mevalonate pathway. The protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 48 kDa

Gene ID: 2222

NCBI Accession: NP_004453

UniProt: P37268

Pathways: Regulation of Lipid Metabolism by PPARalpha