CHN2 antibody

Catalog No. ABIN2463475

Product Details anti-CHN2 Antibody

Target: CHN2 (Chimerin (Chimaerin) 2 (CHN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHN2.

Application Details

Application Notes: CHN2 antibody can be used for detection of CHN2 by ELISA at 1:62500. CHN2 antibody can be used for detection of CHN2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store CHN2 antibody at -20 °C.

Target Details for CHN2

Target: CHN2 (Chimerin (Chimaerin) 2 (CHN2))

Alternative Name: CHN2 (CHN2 Products)

Synonyms: 1700026N20Rik antibody, 4930557O16Rik antibody, ARHGAP3 antibody, Bch antibody, BCH antibody, CHN2-3 antibody, RHOGAP3 antibody, chimerin 2 antibody, chimerin 2 L homeolog antibody, chn2 antibody, CHN2 antibody, Chn2 antibody, chn2.L antibody

Background: CHN2 is a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. CHN2 plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men.This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Molecular Weight: 38 kDa

Gene ID: 1124

NCBI Accession: NP_001035025

UniProt: P52757