TCEB1 antibody

Catalog No. ABIN2463870

Product Details anti-TCEB1 Antibody

Target: TCEB1 (Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) (TCEB1))

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCEB1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TCEB1.

Application Details

Application Notes: TCEB1 antibody can be used for detection of TCEB1 by ELISA at 1:7812500. TCEB1 antibody can be used for detection of TCEB1 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store TCEB1 antibody at -20 °C.

Target Details for TCEB1

Target: TCEB1 (Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) (TCEB1))

Alternative Name: TCEB1 (TCEB1 Products)

Synonyms: 2610043E24Rik antibody, 2610301I15Rik antibody, AA407206 antibody, AI987979 antibody, AW049146 antibody, SIII antibody, eloC antibody, TCEB1 antibody, fb09f09 antibody, wu:fb09f09 antibody, zgc:111990 antibody, zgc:92635 antibody, elongin C antibody, elongin C L homeolog antibody, transcription elongation factor B (SIII), polypeptide 1b antibody, Eloc antibody, eloc.L antibody, ELOC antibody, tceb1b antibody

Background: TCEB1 is known as protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Western blots using two different antibodies (P100962-T200 and P100963_P050 / P100963_P100) against two unique regions of this protein target confirm the same apparent molecular weight in our tests.

Molecular Weight: 12 kDa

Gene ID: 6921

NCBI Accession: NP_005639

UniProt: Q15369

Pathways: SARS-CoV-2 Protein Interactome