MITF antibody (AA 287-417)

Catalog No. ABIN2467990

Product Details anti-MITF Antibody

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Binding Specificity: AA 287-417

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This MITF antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Immunoaffinity Purified

Application Details

Application Notes: Microphthalmia-associated transcription factor antibody can be used for the detection of Microphthalmia-associated transcription factor by Western Blot.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Preservative: Without preservative

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: MITF antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Target Details for MITF

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Alternative Name: MITF (MITF Products)

Synonyms: MITF antibody, ws2a antibody, mitfa antibody, MITF-A antibody, LOC100313655 antibody, mitfb antibody, CMM8 antibody, MI antibody, WS2 antibody, WS2A antibody, bHLHe32 antibody, BCC2 antibody, Bhlhe32 antibody, Gsfbcc2 antibody, Vitiligo antibody, Wh antibody, bw antibody, mi antibody, vit antibody, MITF-H antibody, MITF-M antibody, CMI9 antibody, melanogenesis associated transcription factor antibody, microphthalmia-associated transcription factor antibody, microphthalmia-associated transcription factor S homeolog antibody, Microphthalmia antibody, MITF antibody, mitf antibody, LOC100313655 antibody, mitf.S antibody, LOC100534525 antibody, MICROP antibody, Mitf antibody

Background: FUNCTION: Transcription factor for tyrosinase and tyrosinase-related protein 1. Binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') found in the tyrosinase promoter. Plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

DISEASE: Defects in MITF are the cause of Tietz syndrome [MIM:103500]. It is an autosomal dominant disorder characterized by generalized hypopigmentation and profound, congenital, bilateral deafness. Penetrance is complete

Molecular Weight: 58.8 kDa (calculated)

Gene ID: 4286

NCBI Accession: NP_000239

UniProt: O75030

Pathways: Chromatin Binding