TMEM123 antibody (AA 173-188)

Catalog No. ABIN2470150

Product Details anti-TMEM123 Antibody

Target: TMEM123 (Transmembrane Protein 123 (TMEM123))

Binding Specificity: AA 173-188

Reactivity: Human, Monkey, Rabbit, Gibbon, Gorilla

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM123 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein G Column

Immunogen: TMEM123 antibody was raised against amino acids 173 - 188 of TMEM123 (Human).

Isotype: IgG

Application Details

Application Notes: TMEM123 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: TMEM123 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.

Target Details for TMEM123

Target: TMEM123 (Transmembrane Protein 123 (TMEM123))

Alternative Name: TMEM123 (TMEM123 Products)

Synonyms: KCT3 antibody, PORIMIN antibody, PORMIN antibody, 2310075C12Rik antibody, RGD1305625 antibody, kct3 antibody, pormin antibody, porimin antibody, transmembrane protein 123 antibody, transmembrane protein 123 L homeolog antibody, TMEM123 antibody, Tmem123 antibody, tmem123.L antibody, tmem123 antibody

Background: Porimin was identified by a monoclonal antibody developed by immunizing mice with apoptotic cells. One of these antibodies, designated anti-Porimin (for pro-oncosis receptor inducing membrane injury), was found to directly induce a unique type of cell death in Jurkat cells by binding to a 110- kDa cell surface receptor on Jurkat cells. Anti-Porimin-mediated cell death was preceded by cell aggregation, formation of plasma membrane pores, and the appearance of membrane blebs. More important, these cells show neither DNA fragmentation nor apoptotic bodies, but display lethal damage of the cell membrane.

Gene ID: 114908

UniProt: Q8N131

Pathways: Regulation of Cell Size