Cullin 7 antibody (C-Term)

Catalog No. ABIN2470224

Product Details anti-Cullin 7 Antibody

Target: Cullin 7 (CUL7)

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cullin 7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Delipidation and Defibrination

Immunogen: Cullin 7 antibody was raised against a peptide near the C-Terminus of Cullin 7 (Human) Amino acids 1679-1698.

Application Details

Application Notes: Cullin 7 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Serum, 0.01 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store Cullin 7 antibody at 4 °C or -20 °C.

Target Details for Cullin 7

Target: Cullin 7 (CUL7)

Alternative Name: Cullin 7 (CUL7 Products)

Synonyms: cullin-7 antibody, CUL7 antibody, Cullin-7 antibody, KIAA0076 antibody, dJ20C7.5 antibody, 2510004L20Rik antibody, AA409809 antibody, C230011P08Rik antibody, p185 antibody, p193 antibody, cullin 7 antibody, CUL7 antibody, Cul7 antibody

Background: Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 7 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 7 seems to be involved proteosomal degradation of proteins involved in endothelial proliferation and/or differentiation. Cullin 7 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Cullin 7 interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.

Gene ID: 9820

UniProt: Q14999

Pathways: ER-Nucleus Signaling