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PPARG antibody (C-Term)

PPARG Reactivity: Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Pig, Hamster, Macaque, Mink, Duck, Squirrel, Orang-Utan WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2470320
  • Target See all PPARG Antibodies
    PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
    Binding Specificity
    • 21
    • 18
    • 16
    • 16
    • 16
    • 14
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 156
    • 108
    • 95
    • 34
    • 32
    • 24
    • 21
    • 20
    • 14
    • 9
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Pig, Hamster, Macaque, Mink, Duck, Squirrel, Orang-Utan
    Host
    • 148
    • 18
    • 3
    • 2
    Rabbit
    Clonality
    • 152
    • 20
    Polyclonal
    Conjugate
    • 85
    • 14
    • 11
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    This PPARG antibody is un-conjugated
    Application
    • 154
    • 59
    • 55
    • 52
    • 52
    • 30
    • 22
    • 16
    • 14
    • 13
    • 7
    • 5
    • 5
    • 4
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    Immunoaffinity Chromatography
    Immunogen
    PPARG antibody was raised against amino acids from the C-Terminus of PPARG (Human).
    Top Product
    Discover our top product PPARG Primary Antibody
  • Application Notes
    PPARG antibody can be used in Western Blot starting at 1:200 - 1:1000, and immunohistochemistry starting at 1:50.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    As with all antibodies avoid freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store PPARG antibody at 4 °C or -20 °C.
  • Target
    PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
    Alternative Name
    PPARG (PPARG Products)
    Synonyms
    PPAR gamma antibody, PPARg2 antibody, PPARG antibody, Nr1c3 antibody, PPAR-gamma antibody, PPAR-gamma2 antibody, PPARgamma antibody, PPARgamma2 antibody, NR1C3 antibody, CIMT1 antibody, GLM1 antibody, PPARG1 antibody, PPARG2 antibody, xPPAR-gamma antibody, PPAR-GAMMA antibody, PPARGAMMA antibody, peroxisome proliferator-activated receptor gamma antibody, peroxisome proliferator activated receptor gamma antibody, peroxisome proliferator activated receptor gamma L homeolog antibody, PPARG antibody, Pparg antibody, pparg.L antibody
    Background
    Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.
    Gene ID
    5468
    UniProt
    P37231
    Pathways
    MAPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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