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SPRY4 antibody (AA 306-322)
SPRY4
Reactivity: Human, Chimpanzee
WB, ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SPRY4 Antibody
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Target
See all SPRY4 Antibodies
SPRY4
(Sprouty RTK Signaling Antagonist 4 (SPRY4))
Binding Specificity
All epitopes for SPRY4 antibodies
AA 306-322
Reactivity
All reactivities for SPRY4 antibodies
Human, Chimpanzee
Host
All hosts for SPRY4 antibodies
Rabbit
Clonality
All clonalities for SPRY4 antibodies
Polyclonal
Conjugate
All conjugates for SPRY4 antibodies
This SPRY4 antibody is un-conjugated
Application
All applications for SPRY4 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Purification
Immunoaffinity Chromatography
Immunogen
SPRY4 antibody was raised against amino acids 306-322 of SPRY4 (Human).
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Alternatives
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Application Details
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Application Notes
SPRY4 antibody can be used in Western Blot, immunohistochemistry starting at 1:200, and immunoprecipitation.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
As with all antibodies avoid freeze/thaw cycles.
Storage
4 °C/-20 °C
Storage Comment
Store SPRY4 antibody at 4 °C or -20 °C.
Target Details for SPRY4
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Target
SPRY4
(Sprouty RTK Signaling Antagonist 4 (SPRY4))
Alternative Name
SPRY4 (SPRY4 Products )
Synonyms
SPRY4 antibody, LOC100218545 antibody, HH17 antibody, A030006O18Rik antibody, sprouty4 antibody, sprouty RTK signaling antagonist 4 antibody, sprouty (Drosophila) homolog 4 antibody, sprouty homolog 4 (Drosophila) antibody, Spry4 antibody, SPRY4 antibody, spry4 antibody
Background
Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS. SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine.
Gene ID
81848
UniProt
Q9C004
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