TNFRSF1A antibody (Tumor Necrosis Factor Receptor Superfamily, Member 1A) (AA 20-43) (FITC)

Details for Product anti-TNFRSF1A Antibody No. ABIN2482038, Supplier: Log in to see
Antigen
  • fpf
  • p55
  • tbp1
  • p55-r
  • tnf-r
  • tnfar
  • tnfr1
  • cd120a
  • tnfr55
  • tnfr60
  • xtnfr1
  • TNFR I
  • TNFRSF1A
  • TNFR1
  • CD120a
  • FPF
  • MS5
  • TBP1
  • TNF-R
  • TNF-R-I
  • TNF-R55
  • TNFAR
  • TNFR1-d2
  • TNFR55
  • TNFR60
  • p55-R
  • p60
  • TNF-R1
  • TNF-alphaR1
  • TNFRI
  • TNFRp55
  • TNFalpha-R1
  • Tnfr-2
  • Tnfr1
  • wu:fj65b10
  • zgc:85914
  • tumor necrosis factor receptor superfamily, member 1A
  • tumor necrosis factor receptor superfamily, member 1a
  • tnfrsf1a
  • TNFRSF1A
  • Tnfrsf1a
Alternatives
anti-Human TNFRSF1A antibody for Flow Cytometry
Epitope
AA 20-43
51
36
25
19
15
14
12
11
7
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6
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5
5
5
5
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Monkey, Mouse (Murine), Rabbit, Rat (Rattus)
381
183
110
60
54
51
46
16
14
9
9
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8
4
3
2
1
1
Host
Rabbit
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139
22
17
16
15
1
Clonality
Polyclonal
Conjugate
This TNFRSF1A antibody is conjugated to FITC
33
27
27
13
12
9
8
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6
4
4
4
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3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
298
182
149
112
108
83
46
42
30
23
22
17
13
7
7
7
7
4
3
2
2
2
2
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues
Specificity Detects ~55 kDa.
Purification Peptide Affinity Purified
Alternative Name TNFR1 (TNFRSF1A Antibody Abstract)
Background The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
Gene ID 9606
UniProt P19438
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C
Application Notes
  • WB (1:1000)
  • IHC (1:100)
  • ICC/IF (1:100)
  • optimal dilutions for assays should be determined by the user.
Comment

1 μg/ml of SPC-170 was sufficient for detection of TNFR1 in 20 μg of Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 20-43) antibody (FITC) (ABIN2482038) Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-TNF-R1 Polyclonal A...
Immunohistochemistry (IHC) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 20-43) antibody (FITC) (ABIN2482038) Immunohistochemistry analysis using Rabbit Anti-TNF-R1 Polyclonal Antibody . Tissue: ...
Western Blotting (WB) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 20-43) antibody (FITC) (ABIN2482038) Western blot analysis of Mouse Liver cell lysates showing detection of ~55 kDa TNF-R1...
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 20-43) antibody (FITC) (ABIN2482038) Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-TNF-R1 Polyclonal A...
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 20-43) antibody (FITC) (ABIN2482038) Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-TNF-R1 Polyclonal A...
Background publications Kontermann, Münkel, Neumeyer, Müller, Branschädel, Scheurich, Pfizenmaier: "A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action." in: Journal of immunotherapy (Hagerstown, Md. : 1997), Vol. 31, Issue 3, pp. 225-34, 2008 (PubMed).

Hehlgans, Pfeffer: "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games." in: Immunology, Vol. 115, Issue 1, pp. 1-20, 2005 (PubMed).

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