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SHANK1 antibody (AA 469-691) (PerCP)

SHANK1 Reactivity: Rat WB, IHC, AA Host: Mouse Monoclonal N22-21 (Formerly S22-21) PerCP
Catalog No. ABIN2483713
  • Target See all SHANK1 Antibodies
    SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))
    Binding Specificity
    • 15
    • 12
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 469-691
    Reactivity
    • 32
    • 18
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 30
    • 17
    Mouse
    Clonality
    • 30
    • 17
    Monoclonal
    Conjugate
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SHANK1 antibody is conjugated to PerCP
    Application
    • 40
    • 17
    • 13
    • 13
    • 10
    • 6
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Antibody Array (AA)
    Specificity
    Detects ~190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1
    Clone
    N22-21 (Formerly S22-21)
    Isotype
    IgG1
    Top Product
    Discover our top product SHANK1 Primary Antibody
  • Application Notes
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN2483713 was sufficient for detection of Shank1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))
    Alternative Name
    SHANK1 (SHANK1 Products)
    Synonyms
    SPANK-1 antibody, SSTRIP antibody, synamon antibody, Shank1a antibody, Spank1 antibody, Sstrip antibody, SH3 and multiple ankyrin repeat domains 1 antibody, SHANK1 antibody, Shank1 antibody
    Background
    Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).
    Gene ID
    78957
    NCBI Accession
    NP_113939
    UniProt
    Q9WV48
    Pathways
    Synaptic Membrane, Maintenance of Protein Location
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