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Erythrocyte Ankyrin antibody (AA 1-1881) (APC)

ANK1 Reactivity: Human WB, IHC, ICC, IF Host: Mouse Monoclonal S388A-10 APC
Catalog No. ABIN2485531
  • Target See all Erythrocyte Ankyrin (ANK1) Antibodies
    Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))
    Binding Specificity
    • 10
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 1-1881
    Reactivity
    • 27
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 13
    • 12
    • 1
    • 1
    Mouse
    Clonality
    • 15
    • 12
    Monoclonal
    Conjugate
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Erythrocyte Ankyrin antibody is conjugated to APC
    Application
    • 23
    • 16
    • 12
    • 10
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    Detects ~200 kDa. Does not cross-react with Ankyrin-B or Ankyrin-G.
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R
    Clone
    S388A-10
    Isotype
    IgG2b
    Top Product
    Discover our top product ANK1 Primary Antibody
  • Application Notes
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Comment

    A 1:100 dilution of ABIN2485531 was sufficient for detection of Ankyrin R in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))
    Alternative Name
    Ankyrin R (ANK1 Products)
    Synonyms
    CHANK1 antibody, wu:fa09h06 antibody, zgc:101835 antibody, ank antibody, sph1 antibody, sph2 antibody, ANK1 antibody, ANK antibody, SPH1 antibody, SPH2 antibody, Ank-1 antibody, nb antibody, pale antibody, ankyrin 1 antibody, ankyrin 1, erythrocytic a antibody, ankyrin 1 L homeolog antibody, ankyrin 1, erythrocytic antibody, ankyrin 1, erythroid antibody, ANK1 antibody, ank1a antibody, ank1 antibody, ank1.L antibody, Ank1 antibody
    Background
    Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. Ankyrin R, or Ank1, was first discovered in erythrocyres, but has since also been located in the brain and muscles. Mutations are associated with hereditary spehrocytosis and alzheimer's diease (2).
    Gene ID
    286
    NCBI Accession
    NP_000028
    UniProt
    P16157
    Pathways
    Synaptic Membrane
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