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SCN3B antibody (AA 1-215) (PerCP)

SCN3B Reactivity: Rat WB, ICC, IF Host: Mouse Monoclonal S396-29 PerCP
Catalog No. ABIN2485590
  • Target See all SCN3B Antibodies
    SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))
    Binding Specificity
    • 15
    • 11
    • 1
    • 1
    • 1
    • 1
    AA 1-215
    Reactivity
    • 33
    • 13
    • 9
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    Rat
    Host
    • 27
    • 11
    Mouse
    Clonality
    • 28
    • 10
    Monoclonal
    Conjugate
    • 10
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SCN3B antibody is conjugated to PerCP
    Application
    • 36
    • 13
    • 13
    • 10
    • 10
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    Detects ~40 kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1-215 (full-length) of rat NavBeta3
    Clone
    S396-29
    Isotype
    IgG2b
    Top Product
    Discover our top product SCN3B Primary Antibody
  • Application Notes
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    A 1:100 dilution of ABIN2485590 was sufficient for detection of NavBeta3 in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))
    Alternative Name
    NaVbeta3 (SCN3B Products)
    Synonyms
    1110001K16Rik antibody, 4833414B02Rik antibody, Scnb3 antibody, HSA243396 antibody, SCNB3 antibody, sodium voltage-gated channel beta subunit 3 antibody, sodium channel, voltage-gated, type III, beta antibody, SCN3B antibody, Scn3b antibody
    Background
    Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).
    Gene ID
    245956
    NCBI Accession
    NP_620797
    UniProt
    Q9JK00
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